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Harfouch, Rim M.
- A Survey on the Most Common Side Effects of Isotretinoin among a Group of Syrian Patients
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Authors
Rim M. Harfouch
1,
Jawa Bitar
1,
Rawan Badawi
1,
Ali Salloum
1,
Ali Spih
1,
Nihal Marashli
1,
Mounzer Boubou
2,
Faten Chouman
1
Affiliations
1 Department of Biochemistry, Alsham Private University, Latakia, SY
2 Department of Staistics, Tishreen University. Latakia, SY
1 Department of Biochemistry, Alsham Private University, Latakia, SY
2 Department of Staistics, Tishreen University. Latakia, SY
Source
Research Journal of Pharmacy and Technology, Vol 12, No 1 (2019), Pagination: 40-42Abstract
Acne vulgaris is considered one of the most important cutaneous conditions affecting people in the society at the ages of adolescence and youth. There are many topical treatments along with systemic treatments that can be used to treat it. Isotretinoin is one of the most popular medications that can be used to treat acne vulgaris. Its use can be accompanied by serious side effects; especially teratogenicity. We aimed of this study to evaluate the most common side effects associated to oral isotretinoin intake among the Syrian society to increase the awareness among young adults. We designed an electronic questionnaire containing 20 questions and directed to patients who are treated with oral isotretinoin; taking in consideration the privacy of the questionnaire. 320 individuals (292 females – 28 males from all Syrian communities answered the questionnaire. Among all participants, 8.4% had taken oral isotretinoin without a medical prescription and 55% (176 of 320) had not done liver function tests before starting the course. We noticed that the most frequent side effect was chapped and dry lips 96.3%, and secondly dermatoxerasia 81.6%. It was surprising that 55.6% of all participants suffered from mood disorders and depression. These results confirm the importance of the survey in shedding light on isotretinoin side effects and increasing the awareness of its possible complications, in addition to educate the patients about the effects of this medication on the mental state along with mood disorders that may be associated to long-term use.Keywords
Survey, Isotretinoin, Oral Administration, Side Effects.References
- Gollnick HP, Zouboulis CC, Akamatsu H, Kurokawa I, Schulte A. Pathogenesis and pathognesis-related treatment of acne. J Dermatol. 1991;18:489–99.
- Sanjay K Rathi. ACNE VULGARIS TREATMENT: THE CURRENT SCENARIO. Indian J Dermatol. 2011 Jan-Feb; 56(1): 7–13.
- Diane K. Wysowski, Marilyn Pitts, Julie Beitz. An analysis of reports of depression and suicide in patients treated with isotretinoin. JAAD October 2001Volume 45, Issue 4, Pages 515– 519.
- Piotr Brzezinski, Katarzyna Borowska, Anca Chiriac, Janusz Smigielski. Adverse effects of isotretinoin: A large, retrospective review. Dermatologic Therapy. 2017;30: e12483.
- Borovaya, A., Dombrowski, Y., Zwicker, S., Olisova, O., Ruzicka, T., Wolf, R., et al. (2014). Isotretinoin therapy changes the expression of antimicrobial peptides in acne vulgaris. Archives of Dermatological Research ,306, 689–700.
- Parinitha Rao K, Ramesh Bhat M, Nandakishore B, Dandakeri S, Martis J, et al. (2014) Safety and efficacy of low-dose isotretinoin in the treatment of moderate to severe Acne vulgaris. Indian Journal Dermatology 59: 316
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- Antibacterial Activity of Essential Oils of Rosmarinus officinalis, Salvia officinalis and Anthemis nobilis Widespread in the Syrian Coast
Abstract Views :333 |
PDF Views:0
Authors
Rim M. Harfouch
1,
Manal Darwish
2,
Wisam Al-Asadi
2,
Ali F. Mohammad
3,
Nour M. Gharib
1,
Mohammad Haroun
3
Affiliations
1 Department of Microbiology and Biochemistry, Al Andalus University, Tartous, SY
2 Department of Pharmacognosy and Phytochemistry, Al Andalus University, Tartous, SY
3 Department of Pharmaceutical Chemistry and Quality Control, Al Andalus University, Tartous, SY
1 Department of Microbiology and Biochemistry, Al Andalus University, Tartous, SY
2 Department of Pharmacognosy and Phytochemistry, Al Andalus University, Tartous, SY
3 Department of Pharmaceutical Chemistry and Quality Control, Al Andalus University, Tartous, SY
Source
Research Journal of Pharmacy and Technology, Vol 12, No 7 (2019), Pagination: 3410-3412Abstract
We aimed in this study to determine the antibacterial efficacy of essential oils of Rosmarinus officinalis, Salvia officinalis leaves and Anthemis nobilis flowers widespread in the Syrian coast against several strains of Staphylococcus aureus and Pseudomonas aeruginosa. The essential oils were extracted and the yield was measured using Clevenger apparatus. In vitro investigation of antibacterial activity using agar disc diffusion method and minimal inhibitory concentration (MIC) of each essential oil was determined by microdilution method against studied bacteria. Results demonstrated that Rosmarinus officinalis essential oil had the highest activity (MIC for Staphylococcus aureus was 3.9μl/ml and MIC for Pseudomonas aeruginosa was 7.8 μl/ml). Salvia officinalis essential oil had moderate antibacterial effect with MIC of 31.2 μl/ml and 125μl/ml against Staphylococcus aureus and Pseudomonas aeruginosa respectively. On the other hand, Anthemis nobilis essential oil had no efficacy against tested bacterial strains. According to our study, Rosmarinus officinalis essential oil exhibited higher antibacterial activity against both Staphylococcus aureus and Pseudomonas aeruginosa than this of Salvia officinalis.Keywords
Rosemary, Sage, Chamomile, Essential Oils, Antibacterial Activity, MIC.References
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- Valero M, Salmerón MC. Antibacterial activity of 11 essential oils against Bacillus cereus in tyndallized carrot broth. Int J Food Microbiol. 85; 2003:73–81.
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- Tadrent W, Bachari K, Kabouche Z. Comparative Compositions and Antibacterial Activity of the essential oils of Anthemis nobilis l. and Anthemis mixta l. (asteraceae). International Journal of Pharmacy and Pharmaceutical Sciences. Vol 8, Issue 7; 2016: 457-59.
- Al-Snafi A E. Medical importance of Anthemis nobilis (Chamaemelum nobile) - A Review. AJPST. 6(2); 2016: 89-95.
- Harfouch R.M., Mohammad R., Suliman H. Antibacterial activity of Syrian propolis extract against several strains of bacteria in vitro. World J. Pharm. Pharmaceuti. Sci., 6 (2016), pp. 42-46.
- Zam W, Harfouch R, Bittar S, Sayegh M. Antibacterial activity of various Syrian honey types against Pseudomonas aueruginosa. Research Journal of Pharmacognosy and Phytochemistry 2017; 9(2):73-76.
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- Hussain A, Anwar F, Chatha A, Jabbar A, Mahboob S, and Nigam P. Rosmarinus officinalis essential oil: antiproliferative, antioxidant and antibacterial activities. Brazilian Journal of Microbiology, 41; 2010: 1070-1078.
- Bozin B, Mimica-Dukic N, Samojlik I, Jovin E. Antimicrobial and Antioxidant Properties of Rosemary and Sage (Rosmarinus officinalis L. and Salvia officinalis L., Lamiaceae) Essential Oils J. Agric. Food Chem. 55; 2007:7879–7885.
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